abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the microenvironment and how this affects PDAC progression. Transcriptome expression profiles of PDAC tissues with different perineural invasion status were compared, and the i...

journal_title：Cancer research

authors： Yang MW,Tao LY,Jiang YS,Yang JY,Huo YM,Liu DJ,Li J,Fu XL,He R,Lin C,Liu W,Zhang JF,Hua R,Li Q,Jiang SH,Hu LP,Tian GA,Zhang XX,Niu N,Lu P,Shi J,Xiao GG,Wang LW,Xue J,Zhang ZG,Sun YW

更新日期：2020-05-15 00:00:00

abstract：:Osimertinib, a mutant-specific third-generation EGFR tyrosine kinase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFRL858R -induced lung adenocarcinoma...

journal_title：Cancer research

authors： Starrett JH,Guernet AA,Cuomo ME,Poels KE,van Alderwerelt van Rosenburgh IK,Nagelberg A,Farnsworth D,Price KS,Khan H,Ashtekar KD,Gaefele M,Ayeni D,Stewart TF,Kuhlmann A,Kaech SM,Unni AM,Homer R,Lockwood WW,Michor F,G

更新日期：2020-05-15 00:00:00

abstract：:Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multip...

journal_title：Cancer research

authors： Judge SM,Deyhle MR,Neyroud D,Nosacka RL,D'Lugos AC,Cameron ME,Vohra RS,Smuder AJ,Roberts BM,Callaway CS,Underwood PW,Chrzanowski SM,Batra A,Murphy ME,Heaven JD,Walter GA,Trevino JG,Judge AR

更新日期：2020-05-01 00:00:00

abstract：:Cancer is a major health concern and a leading cause of mortality. The reliable identification of carcinogens and understanding of carcinogenicity has become a main focus of biomedical research and regulatory toxicology. While biomedical research applies cellular in vitro methods to uncover the underlying mechanisms c...

journal_title：Cancer research

authors： Stolz A,Becker M,Wistorf E,Ertych N

更新日期：2020-04-15 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-agent preclinical activity in cancers with high levels of replication st...

journal_title：Cancer research

authors： Rogers RF,Walton MI,Cherry DL,Collins I,Clarke PA,Garrett MD,Workman P

更新日期：2020-04-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiotherapy, chemotherapy, or a combination of these modalities, and surgery remains the only curative intervention for localized disease. Although cancer-associated fibroblasts (CAF) are abundant in PDAC tumors, the effects of radiotherapy on CAFs and th...

journal_title：Cancer research

authors： Pereira PMR,Edwards KJ,Mandleywala K,Carter LM,Escorcia FE,Campesato LF,Cornejo M,Abma L,Mohsen AA,Iacobuzio-Donahue CA,Merghoub T,Lewis JS

更新日期：2020-04-15 00:00:00

abstract：:Pancreatic cancer is a disease with limited therapeutic options. Resistance to chemotherapies poses a significant clinical challenge for patients with pancreatic cancer and contributes to a high rate of recurrence. Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic reprogramming and upregulates...

journal_title：Cancer research

authors： Mukhopadhyay S,Goswami D,Adiseshaiah PP,Burgan W,Yi M,Guerin TM,Kozlov SV,Nissley DV,McCormick F

更新日期：2020-04-15 00:00:00

abstract：:The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains poor despite decades of effort. The abundant extracellular matrix (ECM) in PDAC comprises a major fraction of the tumor mass and plays various roles in promoting resistance to therapies. However, nonselective depletion of ECM has led to poor patient out...

journal_title：Cancer research

authors： Tian C,Öhlund D,Rickelt S,Lidström T,Huang Y,Hao L,Zhao RT,Franklin O,Bhatia SN,Tuveson DA,Hynes RO

更新日期：2020-04-01 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance. Here, we demonstrate that PDA tumor cell-derived proinflammatory cytokine IL1β is essential for the esta...

journal_title：Cancer research

authors： Das S,Shapiro B,Vucic EA,Vogt S,Bar-Sagi D

更新日期：2020-03-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mito...

journal_title：Cancer research

authors： Martin ML,Adileh M,Hsu KS,Hua G,Lee SG,Li C,Fuller JD,Rotolo JA,Bodo S,Klingler S,Haimovitz-Friedman A,Deasy JO,Fuks Z,Paty PB,Kolesnick RN

更新日期：2020-03-01 00:00:00

abstract：:DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate cancer. Decreased DRAIC expression predicts poor patient outcome in prostate and seven other cancers, while increased DRAIC represses growth of xenografted tumors. Here, we show that cancers with decreased DRAIC expres...

journal_title：Cancer research

authors： Saha S,Kiran M,Kuscu C,Chatrath A,Wotton D,Mayo MW,Dutta A

更新日期：2020-03-01 00:00:00

abstract：:Precise diagnosis and subtyping of kidney tumors are imperative to optimize and personalize treatment decision for patients. Patients with the most common benign renal tumor, renal oncocytomas, may be overtreated with surgical resection because of limited preoperative diagnostic methods that can accurately identify th...

journal_title：Cancer research

authors： Zhang J,Li SQ,Lin JQ,Yu W,Eberlin LS

更新日期：2020-02-15 00:00:00

abstract：:Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors derived from gluconeogenic tissues including liver and kidney, yet the definitive regulatory mechanism remains elusive. Here, we screened an array of transcription regulators and identified the enhancer of zeste homolog 2 (EZH2) as a...

journal_title：Cancer research

authors： Liao K,Deng S,Xu L,Pan W,Yang S,Zheng F,Wu X,Hu H,Liu Z,Luo J,Zhang R,Kuang DM,Dong J,Wu Y,Zhang H,Zhou P,Bei JX,Xu Y,Ji Y,Wang P,Ju HQ,Xu RH,Li B

更新日期：2020-02-15 00:00:00

abstract：:Deleted in colorectal cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed. Recent genomic data highlighted that DCC is the third most frequently mutated gene in melanoma; we...

journal_title：Cancer research

authors： Boussouar A,Tortereau A,Manceau A,Paradisi A,Gadot N,Vial J,Neves D,Larue L,Battistella M,Leboeuf C,Lebbé C,Janin A,Mehlen P

更新日期：2020-02-15 00:00:00

abstract：:Anti-VEGF therapy prolongs recurrence-free survival in patients with glioblastoma but does not improve overall survival. To address this discrepancy, we investigated immunologic resistance mechanisms to anti-VEGF therapy in glioma models. A screening of immune-associated alterations in tumors after anti-VEGF treatment...

journal_title：Cancer research

authors： Long Y,Tao H,Karachi A,Grippin AJ,Jin L,Chang YE,Zhang W,Dyson KA,Hou AY,Na M,Deleyrolle LP,Sayour EJ,Rahman M,Mitchell DA,Lin Z,Huang J

更新日期：2020-02-01 00:00:00

abstract：:Local and metastatic relapses of prostate cancer often occur following attempted curative resection of the primary tumor, and up to 66% of local recurrences are associated with positive margins. Therefore, technologies that can improve the visualization of tumor margins and adjuvant therapies to ablate remaining tumor...

journal_title：Cancer research

authors： Wang X,Ramamurthy G,Shirke AA,Walker E,Mangadlao J,Wang Z,Wang Y,Shan L,Schluchter MD,Dong Z,Brady-Kalnay SM,Walker NK,Gargesha M,MacLennan G,Luo D,Sun R,Scott B,Roy D,Li J,Basilion JP

更新日期：2020-01-15 00:00:00

abstract：:Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients is restricted, such as in poorly vascularized tumor areas. We sh...

journal_title：Cancer research

authors： Kaymak I,Maier CR,Schmitz W,Campbell AD,Dankworth B,Ade CP,Walz S,Paauwe M,Kalogirou C,Marouf H,Rosenfeldt MT,Gay DM,McGregor GH,Sansom OJ,Schulze A

更新日期：2020-01-15 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. He...

journal_title：Cancer research

authors： Seo J,Kim MH,Hong H,Cho H,Park S,Kim SK,Kim J

更新日期：2019-12-15 00:00:00

abstract：:The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of mitochondrial fission factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, that is, mitochondrial dynamics, were overexpressed in pa...

journal_title：Cancer research

authors： Seo JH,Chae YC,Kossenkov AV,Lee YG,Tang HY,Agarwal E,Gabrilovich DI,Languino LR,Speicher DW,Shastrula PK,Storaci AM,Ferrero S,Gaudioso G,Caroli M,Tosi D,Giroda M,Vaira V,Rebecca VW,Herlyn M,Xiao M,Fingerman D,Ma

更新日期：2019-12-15 00:00:00

abstract：:The discovery of Epstein-Barr virus (EBV) in 1964 gave birth to the field of viral oncology. Despite significant scientific and clinical developments in research on several other viruses discovered and linked to cancer risk much later, our understanding of EBV as a carcinogen and a possible target for therapeutic inte...

journal_title：Cancer research

authors： Mbulaiteye SM,Prokunina-Olsson L

更新日期：2019-12-01 00:00:00

abstract：:There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Develo...

journal_title：Cancer research

authors： Rodríguez-Barbeito P,Díaz-Botana P,Gago-Arias A,Feijoo M,Neira S,Guiu-Souto J,López-Pouso Ó,Gómez-Caamaño A,Pardo-Montero J

更新日期：2019-12-01 00:00:00

abstract：:Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance. In clear cell renal cell carcinoma (ccRCC), AXL expression is associated with antiangiogenic resistance and poor survival. He...

journal_title：Cancer research

authors： Xiao Y,Zhao H,Tian L,Nolley R,Diep AN,Ernst A,Fuh KC,Miao YR,von Eyben R,Leppert JT,Brooks JD,Peehl DM,Giaccia AJ,Rankin EB

更新日期：2019-11-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the United States. The deoxynucleoside analogue gemcitabine is among the most effective therapies to treat PDAC, however, nearly all patients treated with gemcitabine either fail to respond or rapidly develop resistance. One hallmark of PDA...

journal_title：Cancer research

authors： Dalin S,Sullivan MR,Lau AN,Grauman-Boss B,Mueller HS,Kreidl E,Fenoglio S,Luengo A,Lees JA,Vander Heiden MG,Lauffenburger DA,Hemann MT

更新日期：2019-11-15 00:00:00

abstract：:ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A...

journal_title：Cancer research

authors： Fukumoto T,Fatkhutdinov N,Zundell JA,Tcyganov EN,Nacarelli T,Karakashev S,Wu S,Liu Q,Gabrilovich DI,Zhang R

更新日期：2019-11-01 00:00:00

abstract：:Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic KRAS are still under investigation or awaiting clinical approval. Using a specific KRAS-dependent gene signature, we implemented a computer-assisted inspection o...

journal_title：Cancer research

authors： Mottini C,Tomihara H,Carrella D,Lamolinara A,Iezzi M,Huang JK,Amoreo CA,Buglioni S,Manni I,Robinson FS,Minelli R,Kang Y,Fleming JB,Kim MP,Bristow CA,Trisciuoglio D,Iuliano A,Del Bufalo D,Di Bernardo D,Melisi D,Dra

更新日期：2019-11-01 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient cha...

journal_title：Cancer research

authors： Peres LC,Mallen AR,Townsend MK,Poole EM,Trabert B,Allen NE,Arslan AA,Dossus L,Fortner RT,Gram IT,Hartge P,Idahl A,Kaaks R,Kvaskoff M,Magliocco AM,Merritt MA,Quirós JR,Tjonneland A,Trichopoulou A,Tumino R,van Gils

更新日期：2019-10-15 00:00:00

abstract：:Better therapies are urgently needed for ovarian cancer, which is associated with an overall median survival of less than 5 years from diagnosis. In this issue of Cancer Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in different isotypes of ovarian cancer and that...

journal_title：Cancer research

authors： Carbone M,Melino G

更新日期：2019-10-15 00:00:00

abstract：:The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tol...

journal_title：Cancer research

authors： Park DS,Robertson-Tessi M,Luddy KA,Maini PK,Bonsall MB,Gatenby RA,Anderson ARA

更新日期：2019-10-15 00:00:00

abstract：:Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, the role of GLK in cancer recurrence remains unclear. Here, we report that transgenic GLK promotes tumor metastasis and cell migration through the scaffold protein IQ motif-containin...

journal_title：Cancer research

authors： Chuang HC,Chang CC,Teng CF,Hsueh CH,Chiu LL,Hsu PM,Lee MC,Hsu CP,Chen YR,Liu YC,Lyu PC,Tan TH

更新日期：2019-10-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment and occurs through mechanistic mediators that remain unclear. Here, w...

journal_title：Cancer research

authors： Trillo-Tinoco J,Sierra RA,Mohamed E,Cao Y,de Mingo-Pulido Á,Gilvary DL,Anadon CM,Costich TL,Wei S,Flores ER,Ruffell B,Conejo-Garcia JR,Rodriguez PC

更新日期：2019-10-01 00:00:00

abstract：:DIS3-like 3'-5' exoribonuclease 2 (DIS3L2) degrades aberrant RNAs, however, its function in tumorigenesis remains largely unexplored. Here, aberrant DIS3L2 expression promoted human hepatocellular carcinoma (HCC) progression via heterogeneous nuclear ribonucleoproteins (hnRNP) U-mediated alternative splicing. DIS3L2 d...

journal_title：Cancer research

authors： Xing S,Li Z,Ma W,He X,Shen S,Wei H,Li ST,Shu Y,Sun L,Zhong X,Huangfu Y,Su L,Feng J,Zhang X,Gao P,Jia WD,Zhang H

更新日期：2019-10-01 00:00:00

abstract：:Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-ind...

journal_title：Cancer research

authors： Sun M,Veschi V,Bagchi S,Xu M,Mendoza A,Liu Z,Thiele CJ

更新日期：2019-10-01 00:00:00

abstract：:Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical changes in the cancer cell and its microenvironment. Cells with metastatic potential are often characterized by altered cellular contractility and deformability, lending them the flexibility to disseminate and navigate through dif...

journal_title：Cancer research

authors： Surcel A,Schiffhauer ES,Thomas DG,Zhu Q,DiNapoli KT,Herbig M,Otto O,West-Foyle H,Jacobi A,Kräter M,Plak K,Guck J,Jaffee EM,Iglesias PA,Anders RA,Robinson DN

更新日期：2019-09-15 00:00:00

abstract：:Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

journal_title：Cancer research

authors： Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

更新日期：2019-09-15 00:00:00